Marin Science Seminar Presentations: “Invention in Medicine: How Medical Devices get Invented and Go to Market” Dr. Wallace started out in experimental surgery and radiology studying imaging of the heart using CT scanners. He has worked on a number of devices that originally were built for experimental studies that evolved into clinically useful devices including a cardiac output monitor, the off pump CABG, off pump aneurysm surgery, electronic sedation, and a selective coronary vasodialtor. Dr. Wallace will explain his experiences with the inventive process using examples from both device design and drug development. There will be a brief discussion of the importance of intellectual property, patents, venture capital, FDA approval, and business development in completing the invention process. (December 10, 2008)

“Developing a Drug to Prevent Death!: Perioperative Beta Blockade” This study will detail the efforts to reduce operative mortality. Many approaches have been attempted over the last 40 years. The epidemiology, clinical testing, and finally drug development that resulted in a 50% reduction in operative mortality will be detailed. This project demonstrates how medical therapies are developed and tested. (March 19, 2008)

Dr. Wallace is a Professor of Anesthesiology and Perioperative Care at UCSF Medical Center, and an attending anesthesiologist at the San Francisco VA Medical Center. Dr. Wallace holds a B.S. in Engineering from Yale University and received his M.D. and Ph.D. from Johns Hopkins School of Medicine. His Ph.D. is in Biomedical Engineering. Dr. Wallace completed his anesthesiology residency and a fellowship in Cardiac Anesthesiology at UCSF.